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王耿教授博导

发布时间:2015-05-20来源:澳门新葡亰网站注册点击数:1322

 

左正宏副教授

王耿,博士  Geng Wang, Ph.D.

教授,博士生导师 Professor

细胞生物学 (Cell Biology)

E-mailwangengfuan@163.com


 

1994-1998年,厦门大学化学系,学士学位;

1998-2000年,厦门大学化学系;

2000-2006年,爱荷华大学生物化学系,博士;

2006-2012年,加州大学洛杉矶分校化学与生物化学系,博士后;

2012-2019年,清华大学澳门新葡亰网站注册,特别研究员,博士生导师;

2019-,澳门新葡亰网站注册,教授,博士生导师。

1994-1998     B.S., Department of Chemistry, Xiamen University

1998-2000     Department of Chemistry, Xiamen University

2000-2006     Ph.D., Department of Biochemistry, University of Iowa

2006-2012     Postdoctoral fellow, Department of Chemistry and   

                      Biochemistry, University of California, Los Angeles    

2012-2019     Principle Investigator, Tsinghua University School of LifeSciences

2019-             Professor, Xiamen University School of Life Sciences


 

研究领域(Research Area

线粒体RNA的运输、代谢、和功能,及其和其他重要细胞过程之间的关联和调控

线粒体疾病的医疗研究

哺乳动物正常衰老机制的研究

Mitochondrial RNA import, metabolism, functions, and the regulation network between them and other important cellular processes

Therapeutic research on mitochondrial diseases

Mechanistic study of normal ageing in mammals


 

代表性论文(Selected Publications(*为通讯编辑)

1.Zheng Q, Liu P, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Di F, Tong T, Chen J, Lu Z, Guan J, Wang G*. (2019) Mitochondrion-processed TERC regulates senescence without affecting telomerase activities. Protein Cell, doi: 10.1007/s13238-019-0612-5. [Epub ahead of print].

2.Huang J, Liu P, Wang G*. (2018) Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2). J biol chem, 293, 19633-19644. 

3.Cheng Y, Liu P, Zheng Q, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Tong T, Chen J, Lu Z, Guan J, Wang G*. (2018) Mitochondrial Trafficking and Processing of Telomerase RNA TERC. Cell Reports, 24(10):2589-2595.

4.Liu P, Huang J, Zheng Q, Xie L, Lu X, Jin J, Wang G* (2017) Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2. Protein & Cell 8(1): 735-749.

5.Wang G, Shimada E, Nili M, Koehler CM, Teitell MA (2015) Mitochondria-targeted RNA import. Methods Mol Biol. 1264:107-116.

6.Wang G, Shimada E, Koehler CM, Teitell MA (2012) PNPASE and RNA trafficking into mitochondria. Biochimi Biophys Acta. 1819(9-10):998-1007.

7.Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM (2012) Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A. 109(13):4840-4845.

8.von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C (2012) A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss. Am J Hum Genet. 91(5):919-927.

9.Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC 3rd, Koehler CM, Teitell MA (2010) PNPASE regulates RNA import into mitochondria. Cell. 142(3):456-467.

10.Wang G, Deschenes RJ (2006) Plasma membrane localization of Ras requires class C Vps proteins and functional mitochondria in Saccharomyces cerevisiae. Mol Cell Biol, 26:3243-3255.




荣誉、奖励及参加学术团体的情况Honors and award, Professional service

主持1项科技部国家重点研发计划、1项国家自然科学基金重大研究计划培育项目



 

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