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张宸崧教授博导

发布时间:2015-03-18来源:澳门新葡亰网站注册点击数:6602

张宸崧,博士  ZHANG Chen-Song, Ph.D.林圣彩教授博士生导师

教授 ,博士生导师 Professor

代谢生物学 (Metabolic Biology)

话:+86-592-2184687

传真:+86-592-2187986

E-mail:cszhang@xmu.edu.cn


2006-2010年,澳门新葡亰网站注册,学士学位;

2010-2015年,澳门新葡亰网站注册,博士学位;

2015-2017年,厦门大学化学化工学院,博士后;

2017-2019年,澳门新葡亰网站注册,博士后;

2019-至今,澳门新葡亰网站注册,教授。

2006-2010, School of Life Sciences, Xiamen University, B.S.

2010-2015, School of Life Sciences, Xiamen University, Ph.D.

2015-2017,College of Chemistry and Chemical Engineering, Xiamen University, Post-doctor

2017-2019, School of Life Sciences, Xiamen University, Post-doctor

2019-present, School of Life Sciences, Xiamen University, Professor


研究领域(Research Area)

研究营养物质的感应机制和其对机体代谢稳态的维持与调控的方式,以及在对生理和病理条件下代谢调控的枢纽蛋白,特别是代谢稳态核心调节蛋白AMPK的调控机制和生理功能的研究。


代表性论文(Selected Publications)

1.   Cai WF#, Zhang C, Wu YQ, Zhuang G, Ye Z, Zhang CS*, Lin SC*. Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial mitochondrial fusion. Cell Research. 2018 Jun 22. doi: 10.1038/s41422-018-0057-z. 

2.    Zhang CS#, Hawley SA#, Zong Y#, Li M#, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG*, Lin SC*. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19.

3.   Zhang CS, Li M, Lin SC*. Methods to Study Lysosomal AMPK Activation. Methods Enzymol. 2017;587:465-480. doi: 10.1016/bs.mie. 2016.09.071. Epub 2016 Nov 12.

4.   Zhang CS#, Li M#, Ma T#, Zong Y, Cui J, Feng JW, Wu YQ, Lin SY, Lin SC*. Metformin Activates AMPK through the Lysosomal Pathway. Cell Metabolism. 2016 Oct 11;24(4):521-522. doi: 10.1016/j.cmet. 2016.09.003.

5.  Zhang CS#, Lin SC#*. AMPK Promotes Autophagy by Facilitating Mitochondrial Fission. Cell Metabolism. 2016 Mar 8;23(3):399-401. doi: 10.1016/j.cmet. 2016.02.017.

6.   Zhang CS#, Liu Q#, Li M#, Lin SY#, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC*. RHOBTB3 promotes proteasomal degradation of HIFalpha through facilitating hydroxylation and suppresses the Warburg effect. Cell Research. 2015 Sep;25(9):1025-42. doi: 10.1038/cr. 2015.90. Epub 2015 Jul 28.

7.   Zhang CS#, Jiang B#, Li M#, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC*. The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism. 2014 Sep 2;20(3):526-40. doi: 10.1016/j.cmet. 2014.06.014. Epub 2014 Jul 4.

8.  Zhang YL#, Guo H#, Zhang CS#, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC*. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism. 2013 Oct 1;18(4):546-55. doi: 10.1016/j.cmet. 2013.09.005.


荣誉、奖励及参加学术团体的情况 (Honors and award)

2019入选厦门大学南强青年拔尖人才(A类)

2017年度中国生命科学十大进展

2017年度中国糖尿病十大研究

2017年度邹承鲁杰出研究论文奖

2017年获福建省优秀博士毕业论文

2016年获中国博士后科学基金面上资助

2016年入选第一批中国科协青年人才托举项目

Young Top Talents      Program of Xiamen University (2019)

Top 10 Advances in Life Sciences of China (2017)

Top 10 Diabete Research in China (2017)

Zouchenglu Outstanding Paper Award (2017)

Outstanding Doctoral Thesis Award of Fujian Province (2017)

China Postdoctoral Science Foundation (2016)

Young Talents Support Project of China Association for Science and Technology      (2016)

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