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黄佳良教授博导

发布时间:2016-01-17来源:澳门新葡亰网站注册点击数:10967

             


黄佳良  HUANG Jialiang, Ph.D.

教授,博士生导师

闽江学者特聘教授

生物信息学与表观基因组学(Bioinformatics and Epigenomics)

课题组长

邮箱jhuang@xmu.edu.cn

实验室主页:https://huanglab.xmu.edu.cn/

2005年,福州大学,生物工程学士

2008年,福州大学,计算机App与理论硕士

2012年,中国科学院遗传与发育生物学研究所,生物信息学博士

2011-2013,葛兰素史克上海医药研发有限企业,科学家

2013-2018,哈佛大学Dana-Farber癌症研究所/波士顿儿童医院,博士后

2018年至今,澳门新葡亰网站注册,闽江学者特聘教授

  

2005, B.Sc., Fuzhou University

2008, M.Sc., Fuzhou University

2012, Ph.D., Chinese Academy of Science

2011-2013, Scientist, GlaxoSmithKline (China) R&D Co., Ltd., Shanghai

2013-2018, Postdoc, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School

2018-present, Principal Investigator, School of Life Sciences, Xiamen University

  

研究领域Research Area

 本课题组利用生物信息学(干)和分子生物学(湿)等方法,研究哺乳动物发育和癌症的表观遗传调控机制。围绕某一特定生物知识题,基于现有/产生表观基因组学等图谱,利用生物信息学方法在系统层面提出具体的生物学假设,并采用CRISPR/cas9基因编辑等手段开展实验验证。具体研究方向包括(1)设计生物信息学算法,解决生物组学数据分析的定量问题;(2)整合已有表观基因组学数据,构建发育过程中的增强子动态调控网络,寻找关键调控因子;(3)与临床医生/生物学家合作,利用单细胞组学等技术,探索癌症发生和治疗的细胞异质性,寻找潜在药物靶标。 

Our lab is interest in understanding the epigenetic regulation mechanisms of mammalian development and cancer using computational (dry) and experimental (wet) methods. Starting from a specific biological question, we generate or integrate publicly available genomic and epigenomic data to make a specific testable hypothesis at system level, following by the experimental validation using CRISPR/cas9 genome-editing assays. Our current research includes: (1) developing computational methods for quantification problems for various omics data; (2) elucidate the gene regulatory networks during development through integrating genomic, transcriptomic, and epigenomic data; (3) investigate the cellular heterogeneity during cancer progression and treatment response using single-cell analysis, which helps to identify potential drug targets.

本课题组热诚欢迎具有分子生物学、数理统计和计算机编程等交叉学科基础的硕士生、博士生、博士后和助理教授加盟!


代表性论文Selected Publications 

1.J. Huang#, K. Li#, W. Cai, X. Liu, Y. Zhang, S. H. Orkin, J. Xu*, G.-C. Yuan*. Dissecting super-enhancer hierarchy based on chromatin interactions. Nature Communications, 2018; 9:943.

2.J. Huang#, X. Liu#, D. Li#, Z. Shao#, H. Cao, Y. Zhang, E. Trompouki, T. V. Bowman, L. I. Zon, G.-C. Yuan, S. H. Orkin*, J. Xu*. Dynamic control of enhancer repertoires drives lineage and stage-specific transcription during hematopoiesis. Developmental Cell, 2016; 36, 9-23.

3.J. Huang, E. Marco, L. Pinello, G.-C. Yuan*. Predicting chromatin organization using histone marks. Genome Biology, 2015; 16, 162.

4.J. Huang, C. Niu, C. D.Green, L. Yang, H. Mei*, J.-D. J. Han*. Systematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network. PLoS Computational Biology, 2013; 9, e1002998.

5.J. Huang, Y. Liu, W. Zhang, H. Yu and J.-D. J. Han*. eResponseNet: a package prioritizing candidate disease genes through cellular pathways. Bioinformatics, 2011; 27, 2319-2320.

6.E. Marco#, W. Meuleman#, J. Huang#, K. Glass, L. Pinello, J. Wang, M. Kellis*, G.-C. Yuan*. Multi-scale chromatin state annotation using a hierarchical hidden Markov model. Nature Communications, 2017; 8, 15011.

7.S. Beyaz#, J. Kim#, L. Pinello#, Y. Hu, M. A. Kerenyi, P. P. Das, R. A. Barnitz, M. E. Xifaras, R. Dogum, J. Huang, W. N. Haining, O. Yilmaz, G.-C. Yuan, S. H. Orkin*, F. Winau*. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nature Immunology. 2017; 18, 184-195.

8. H. Xie, C. Peng, J. Huang, B. Li, W. Kim, E. Smith, Y. Fujiwara, J. Qi, G. Cheloni, P. P. Das, M. Nguyen, S. Li, J. E. Bradner, S. H. Orkin*. Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2. Cancer Discovery, 2016; 6, 1237-1247.

9.S. Luc, J. Huang, J. McEldoon, E. Somuncular, D. Li, C. Rhodes, S. Mamoor, S. Hou, J. Xu, S. H. Orkin*. Bcl11a-deficiency causes hematopoietic stem cell defects with an aging-like phenotype. Cell Reports, 2016; 16, 3181-3194.

10.J. Xu#, Z. Shao#, D. Li, H. Xie, W. Kim, J. Huang, J. E. Taylor, L. Pinello, K. Glass, J. D. Jaffe, G.-C. Yuan, S. H. Orkin*. Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular Cell, 2015; 57, 304-316.




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