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4月26日学术报告

发布时间:2019-04-24来源:澳门新葡亰网站注册点击数:220

报告一:

报告题目Mechanism of Interactive Oncogene-Tumor Suppressor Signaling in Cancer

报 告 人:冯新华教授

浙江大学生命科学研究院

国家自然科学基金委杰出青年基金获得者,教育部长江学者讲座教授

报告时间426日下午3:00-4:00

报告地点:澳门新葡亰网站注册E307学术报告厅

联 系 人:彭永莹/田静 2181601

【报告摘要】Loss of the antiproliferative response is a hallmark in human cancers. Tumor cells have developed a number of strategies to escape from negative growth control. One major mechanism to resist the cytostatic effect of anti-growth factor such as TGF-β is through inactivating mutations/deletions in the TGF-β signaling pathway, which frequently occur in gastrointestinal and pancreatic cancer. For example, tumor suppressor Smad4/DPC4, the central transducer of TGF-β signaling, is deleted in more than half of pancreatic cancer patients. However, deletion or mutations in the Smad4 gene are rare in other types of cancers. We have taken functional genomic, proteomic and cell biological approaches to study how the tumor suppressor function is regulated in normal and cancer cells. We found that activation of many oncoproteins can cause TGF-β resistance. Our novel studies gain conceptual insights into the oncoprotein-tumor suppressor interplay in tumorigenesis and provide guidance to logical therapeutic designs in cancer prevention, diagnostics and treatment.


报告二:

报告题目:肠上皮的稳态调控

报 告 人:陈晔光教授

     清华大学教授,中国科学院院士

中国细胞生物学学会理事长

报告时间426日下午4:00-5:00

报告地点:澳门新葡亰网站注册E307学术报告厅

联 系 人:彭永莹/田静 2181601

【个人概况】陈晔光博士,清华大学教授,中科院院士。1996年在美国爱因斯坦医学院获博士学位,之后在纽约Memorial Sloan-Kettering Cancer Center/HHMI从事博士后研究;2000年至2002年为美国加洲大学Riverside分校助理教授;2002年起为清华大学教授。主要从事TGF-βWnt信号转导的研究以及它们在器官发育、干细胞自我更新分化和肿瘤形成中的作用。兼任中国细胞生物学会理事长。先后担任J Biol ChemOpen BiolCell ResBiochem JIntl J Biochem Cell BiolExp Cell Res等杂志编委。获教育部长江学者奖励计划特聘教授、国家自然科学基金委杰出青年基金、中国青年科技奖和何梁何利科技进步奖等。




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