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王维嘉副教授博导

发布时间:2015-03-21来源:澳门新葡亰网站注册点击数:600

王维嘉 Wang Weijia, Ph.D.            

副教授  博士生导师

核受体与细胞应激(Nuclear receptor and Cellular stress

E-mail: wangwj@xmu.edu.cn



2005-2009年,澳门新葡亰网站注册, 学士学位;

2009-2015年,澳门新葡亰网站注册, 博士学位;

2015-2017年,耶鲁大学医学院药理系, 博士后;

2017-2019年,宾夕法尼亚大学医学院转化研究中心, 博士后;

2019年至今,澳门新葡亰网站注册, 副教授。


2005-2009, School of Life Sciences, Xiamen University, Bachelor;

2006-2015, School of Life Sciences, Xiamen University, Ph.D.;

2015-2017, School of Medicine, Yale University, Postdoc Fellow;

2017-2019, Perelman School of Medicine, University of Pennsylvania, Postdoc Fellow;

2019-present, School of Life Sciences, Xiamen University, Associate Professor.


研究领域(Research Area)

1.  围绕核受体的生物学功能开展研究,重点关注核受体的抗肿瘤分子机制以及核受体靶向药物的筛选。

2.  关注细胞在生理或病理应激条件下的应答调控机制,重点探讨细胞如何感应能量代谢并通过核受体等关键节点蛋白实现信号转导,从而影响线粒体功能,决定细胞命运。



代表性论文(Selected Publications) * Corresponding author  # co-first author

1.  Hoshino A#, Wang WJ#, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP1, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M1, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z*. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019, 575: 375-379.

2.   Xiao Q#, Wu JB#, Wang WJ#, Zheng YX, Chang WC, Yu XQ, Meeth K, Sahraei M, Bothwel ALM, Chen LP, Bosenberg M, Li L*, Tang WW* and Wu DQ*. DKK2 imparts tumor immunity evasion through LRP5-mediated suppression of STAT5 signaling and cytotoxic immune cell activation, Nature Medicine. 2018, 24,3,262-270.

3.  He JP#, Hou PP#, Chen QT#, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ*. Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression. Cancer Research. 2018, 78(17):4853-4864.

4.  Bian XL#, Chen HZ#, Yang PB#, Li YP#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420

5.   Wang WJ#, Wang Y#, Hou PP#, Li FW#, Zhou B, Chen HZ, Bian XL, Cai QX, Xing YZ, He JP, Zhang HK, Huang PQ, Lin TW * and Wu Q *. Autophagic death in cancer cells by agonizing TR3 and attenuating Akt2 activity. Chemistry & Biology (renamed as Cell Chemical Biology), 2015; 22(8): 1040-1051.

6.  Li L#, Liu Y#, Chen HZ#, Li FW#, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T*, Wu Q*. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature Chemical Biology. 2015, 11(5):339-46.

7.  Wang WJ#, Wang Y#, Chen HZ#, Xing YZ#, Li FW#, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann Friedrich, Wu M, Han J, Huang PQ, Lin T*, Wu Q*. Orphan nuclear receptor TR3 acts in autophagic cell death of melanoma via a mitochondrial signaling pathway. Nature Chemical Biology. 2014, 10:133-140. 

8.  Chen HZ*#, Wen Q#, Wang WJ, He JP, Wu Q. The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ. The International Journal of Biochemistry & Cell Biology, 2013, 45:1600 – 1609.

9. Wang RH#, He JP#, Su ML#, Luo J#, Xu M, Du XD, Chen, HZ, Wang WJ, Wang Y, Zhang N, Zhao BX, Zhao WX, Shan ZG, Han JH, Chang CS, Wu Q*. The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signaling. EMBO Molecular Medicine. 2013; 1(5), 137-148.

10.  Chen HZ, Li L, Wang WJ, Du XD, Wen Q, He JP, Zhao BX, Li GD, Zhou W, Xia Y, Yang QY, Hew C-L, Liou Y-C*, Wu Q*. Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene.  2012, 312876-2887.

11.Chen HZ#, Liu QF#, Li L#, Wang WJ, Yao LM, Yang M, Liu B, Chen Wei, Zhan YY,  Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signaling. Gut.  2012, 61714-724.

12. Zhan YY#, Chen Y#, Zhang Q#, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi CF, Yang K, Li AZ, Xin YZ, Li Y, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang CS, Huang PQ, Lin TW* and Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology. 2012; 11(8), 897-904.




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