Siqing ZHANG, Ph.D.
1985, B.Sc., Peking University;
1988, M.Sc., Peking University;
1995, Ph.D., Beijing Normal University.
1997-2000, Postdoctoral Fellow, Weizmann Institute of Sciences, Israel;
2000-2006, Postdoctoral Fellow, Harvard Medical School, USA;
2006-Present, Professor, School of Life Sciences, Xiamen University.
Our Laboratory is interested in understanding the molecular basis of signal transduction in normal and cancer cells. In particular, we are interested in studying apoptosis and its role in tumorigenesis. Evasion from apoptosis is a hallmark of cancer. Bcl-2 family proteins are central mediators of apoptosis. We concentrate our efforts on the Bcl-2 family proteins. We are trying to understand how growth factor signaling and the tumor suppressor p53 regulate the activities of the Bcl-2 family proteins. We are utilizing a variety of biochemical, cell biological and RNAi-based approaches to identify new Bcl-2 family interacting proteins and characterizing how these proteins contribute to the regulation of cell death and/or cell survival.
1. Zhao XM, Chen Z, Zhao JB, Zhang PP, Pu YF, Jiang SH, Hou JJ, Cui YM, Jia XL, Zhang SQ*. Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis, 7: e2089, 2016.
2. Li Z, Hou J, Sun L, Wen T, Wang L, Zhao X, Xie Q, Zhang SQ*. NMI mediates transcription-independent ARF regulation in response to cellular stresses. Mol Biol Cell, 23: 1-12, 2012. (*Corresponding author).
3. Zhang SQ, Yang WT, Kontaridis MI, Bivona TG, Wen GY, Araki T, Luo JC, Thompson AJ, Schraven BL, Philips MR, G Neel BG*. Shp2 regulates Src family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell, 13: 341-355, 2004.
4. Zhang SQ, Tsiaras GW, Araki T, Wen GY, Minichiello L, Klein R, Neel BG*. Receptor-specific regulation of PI-3K activation by the protein-tyrosine phosphatase Shp2. Mol Cell Biol, 22: 4062-4072, 2002.
5. Zhang SQ, Kovalenko A, Cantarella G, Wallach D*. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKK?) upon receptor stimulation. Immunity, 12: 301-311, 2000.