Jing YUAN, Ph.D.
2002, B.Sc., China Agricultural University;
2007, Ph.D., China Agricultural University.
2007-2012, Postdoc, NIH, USA;
2012-present, Professor, School of Life Science, Xiamen University.
Malaria remain one of most serious public health thread in the world, causing billions infection cases and millions death cases annually. Because of the lack of the effective vaccine and quick evolving and spreading globally of drug resistant parasite strains, we face the challenge for preventing and controlling malaria globally. Research in our group focus one two area: 1. Identify and characterize the genetic determinants conferring drug resistance in human malaria parasite, study the molecular and cellular mechanism regulating the drug resistance; 2. Based on the mouse malaria parasite model, investigate the signal pathway involved in the hepatocyte invasion and development of parasite sporozoite, we are particularly interested in identifying the host factors and their interaction with parasite factors during the parasite invasion and development in the host cell.
1. Zhang C, Xiao B, Jiang Y, Zhao Y, Li Z, Gao H, Ling Y, Wei J, Li S, Lu M, Su XZ, Cui H*, Yuan J*. Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System. MBio. 2014; 5(4): 01414-14.
2. Jing Yuan, Ken Chih -Chien Cheng, Ronald Johnson, Ruili Huang, David Fidock, James Inglese, Thomas Wellems, Christopher Austin & Xinzhuan Su. Chemical genomic profiling for antimalarial therapies, response signatures and molecular targets. Science. 2011; 333:724-729. (Research article and Cover; Recommended “Exceptional” by “Faculty of 1000 Biology”)
3. Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature Chemical Biology. 2009; 5(10): 765-71.
4. Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, Macarthur R, Su XZ, Inglese J, Porco JA Jr. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A.2011; 108(17): 6775-80.