Shengcai LIN, Ph.D.
1984, B.Sc. Xiamen University;
1991, Ph.D., UT Southwestern Medical Center at Dallas.
1991-1995, Postdoctoral Fellow at the Howard Hughes Medical Institute, UCSD;
1995-2001, Principal Investigator, IMCB, Singapore;
2001-2006, Assistant Professor/Associate Professor (tenured), Hong Kong University of Science and Technology;
2003-Present, Dean, School of Life Sciences, Xiamen University;
2001-Present, Professor, Cheung Kong Scholar, Xiamen University.
Our research lies in the broad area of the molecular mechanisms that underlie metabolic homeostasis and its relationship to cell growth control. We have discovered a signaling pathway comprising the protein kinase GSK3, acetyltransferase TIP60, and protein kinase ULK1, which activates autophagy in cells deprived of serum, elucidating the molecular mechanism linking nutritional starvation to autophagy. More recently, we have that the low-energy signal AMP can autonomously initiate assembly of an activating complex for the energy sensor kinase AMPK. Current interests include further exploration of how AMPK is regulated at the molecular biology, subcellular organelle, and organismal levels, and study of how the autophagy cross-talks to the overall metabolic control or reprogramming. Our ultimate goal is to reveal a unifying mechanism that governs metabolic homeostasis in response to metabolic stresses, and the metabolic checkpoint for cell growth.
1. Hui Luo, Ming Jiang, Guili Lian, Qing Liu, Meng Shi, Terytty Yang Li, Lintao Song, Jing Ye, Ying He, Luming Yao, Cixiong Zhang, Zhi-Zhong Lin, Chen-Song Zhang, Tong-Jin Zhao, Wei-Ping Jia, Peng Li, Shu-Yong Lin,* Sheng-Cai Lin*. AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell Metabolism 2018.（in press）
2. Lin SC*, Hardie DG*. AMPK: Sensing Glucose as well as Cellular Energy Status (Review). Cell Metabolism, 27, Nov 15, 2017.
3. Zhang CS, Hawley S. A., Zong Y, Li MQ, Wang ZC, Gray A., Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye ZY, Lin SY, Yin HY, Piao HL, Hardie DG*, Lin SC*. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature, 548(7665), 112-116, 2017.
4. Zhang CS, Li MQ, Ma T, Zong Y, Cui JW, Feng JW, Wu YQ, Lin SY, Lin SC*. Metformin Activates AMPK through the Lysosomal Pathway. Cell Metabolism, 24(4), 521-522, 2016.
5. Li YT, Sun Y, Liang Y, Liu Q, Shi YZ, Zhang CS, Zhang CX, Song LT, Zhang P, Zhang XZ, Li XT, Chen T, Huang HY, He XD, Wang Y, Wu YQ, Chen SX, Jiang M, Chen CH, Xie CC, James Y. Yang, Lin Y, Zhao SM, Ye ZY, Lin SY, Daniel Tsun-yee Chiu, Lin SC*. ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Molecular Cell, 62(3), 359-370, 2016.
6. Zhang CS, Lin SC*. AMPK Promotes Autophagy by Facilitating Mitochondrial Fission. Cell Metabolism, 23(3), 399-401, 2016.
7. Zhang CS, Jiang B, Li MQ, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC*. The Lysosomal v-ATPase-Ragulator Complex is a Common Activator for AMPK and mTORC1, acting as a Switch between Catabolism and Anabolism. Cell Metabolism, 20(3), 526-540, 2014.
8. Zhang YL, Guo HL, Zhang CS, Lin SY, Li P, Wu JW,Lin SC*. AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism, 18(4), 546-555, 2013.
9. Lin SY, Li TY, Liu Q, Zhang CS, Li X, Chen Y, Zhang SM, Lian GL, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li QX, Han JH, Lin SC*. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science, 336(6080), 477-481, 2012.
10.Li QX, Lin SY, Wang X, Lian GL, Lu ZL, Guo HL, Ruan K, Wang YH, Ye ZY, Han JH, Lin SC*. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biology, 11(9), 1128-1135, 2009.
11.Rui YN, Xu Z, Xiong B, Cao Y, Lin SY, Chan SC, Luo W, Han Y, Lu ZL, Ye ZY, Zhou HM, Han JH, Meng A*, Lin SC*. A ?-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by Aida. Developmental Cell, 13(2), 268-282, 2007.
12.Rui YN, Xu Z, Lin SY, Li QX, Rui HL, Luo W, Zhou HM, Cheung PY, Wu ZG, Ye ZY, Li P, Han JH, Lin SC*. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. The EMBO Journal. 23(23), 4583-4594, 2004.