April 11, 2016-A novel redox pathway in anchorage-independent cell growth
Title: A novel redox pathway in anchorage-independent cell growth
Lecturer: Lei Jiang Ph.D.
Children's Research Institute,
UT Southwestern Medical Center,
Time: PM 4:00, April 11, 2016 (Monday).
Venue: Lecture hall E307, School of Life Sciences.
Invitor: Prof. Shengcai Lin
Lecture Abstract: Using the state of the art integration of CRISPR and metabolic flux analysis (MFA), Dr. Lei Jiang and his colleagues discovered a novel metabolic pathway controls redox homeostasis in anchorage-independent malignant cells. This pathway allows NADPH to be shuttled from the pentose phosphate pathway into the mitochondria. Blocking this novel pathway impairs spheroid growth through uncontrolled oxidative stress.