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April 11, 2016-A novel redox pathway in anchorage-independent cell growth

Post on: 2016-04-07Source: Hits: 89

Title: A novel redox pathway in anchorage-independent cell growth

Lecturer: Lei Jiang Ph.D.

                Children's Research Institute,

                UT Southwestern Medical Center, 

                Dallas, TX.

Time: PM 4:00, April 11, 2016 (Monday).  

Venue:  Lecture hall E307, School of Life Sciences. 

Invitor: Prof. Shengcai Lin

Lecture Abstract: Using the state of the art integration of CRISPR and metabolic flux analysis (MFA), Dr. Lei Jiang and his colleagues discovered a novel metabolic pathway controls redox homeostasis in anchorage-independent malignant cells. This pathway allows NADPH to be shuttled from the pentose phosphate pathway into the mitochondria. Blocking this novel pathway impairs spheroid growth through uncontrolled oxidative stress.


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